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KMID : 0354720070310040372
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Journal of Korean Diabetes Association
2007 Volume.31 No. 4 p.372 ~ p.376
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Case Report : Two Cases of Autoantibody Negative Fulminant Type 1 Diabetes Mellitus
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Cho Hwa-Young
Lee Hong-Kyu
Shin Chan-Soo
Park Do-Joon
Kim Seong-Yeon
Cho Bo-Youn
Park Myoung-Hee
Cho Young-Min
Park Kyong-Soo
Kang Mi-Yeon
Kim Ki-Hwan
Ku Yun-Hyi
Lee Eun-Kyung
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Abstract
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Autoantibody negative fulminant type 1 diabetes mellitus is a novel subtype of type 1 diabetes, which is characterized by a remarkably abrupt onset, metabolic derangement such as diabetic ketoacidosis at diagnosis, low HbA1c level at onset and a negative islet-related autoantibodies. The prevalence of fulminant type 1 diabetes has large difference between Japan and other countries. The precise reason for this regional variation remains to be clarified. One of the possible explanations is genetic background such as genotype of class II HLA molecule. In addition, environment factors including viral infection are suggested as possible pathogenesis of the disease. Only a few cases with fulminant type 1 diabetes have been reported outside Japan, and most of these cases with definite diagnosis have been reported in Korea. We report here on two Korean patients that met the criteria for diagnosis of fulminant type 1 diabetes in accordance with their HLA genotypes.
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KEYWORD
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Fulminant, Human Leukocyte antigen, Type 1 diabetes mellitus
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